Selected Publications
Surugihalli C, Muralidaran V, Ryan CE, Patel K, Zhao D, Sunny NE. (2023) Branched-chain amino acids alter cellular redox to induce lipid oxidation and reduce de novo lipogenesis in the liver. Am J Physiol Endocrinol Metab. 324(4): E299-E313. PMID: 36791321
Kattapuram N, Zhang C, Muyyarikkandy MS, Surugihalli C, Muralidaran V, Gregory T, Sunny NE. (2021) Dietary Macronutrient Composition Differentially Modulates the Remodeling of Mitochondrial Oxidative Metabolism during NAFLD. Metabolites. 11(5):272. PMID: 33926132.
Muyyarikkandy MS, McLeod M, Maguire M, Mahar R, Kattapuram N, Zhang C, Surugihalli C, Muralidaran V, Vavilikolanu K, Mathews CE, Merritt ME, Sunny NE. (2020) Branched chain amino acids and carbohydrate restriction exacerbate ketogenesis and hepatic mitochondrial oxidative dysfunction during NAFLD. FASEB J. 34(11):14832-14849. PMID: 32918763.
Surugihalli C, Porter TE, Chan A, Farley LS, Maguire M, Zhang C, Kattapuram N, Muyyarikkandy MS, Liu HC, Sunny NE. (2019) Hepatic Mitochondrial Oxidative Metabolism and Lipogenesis Synergistically Adapt to Mediate Healthy Embryonic-to-Neonatal Transition in Chicken. Sci Rep. 9(1):20167. PMID: 31882889.
Kalavalapalli S, Bril F, Koelmel JP, Abdo K, Guingab J, Andrews P, Li WY, Jose D, Yost RA, Frye RF, Garrett TJ, Cusi K, Sunny NE. (2018) Pioglitazone improves hepatic mitochondrial function in a mouse model of nonalcoholic steatohepatitis. Am J Physiol Endocrinol Metab. 315(2): E163-E173. PMID: 29634314.
Sunny NE, Bril F, Cusi K. (2017) Mitochondrial Adaptation in Nonalcoholic Fatty Liver Disease: Novel Mechanisms and Treatment Strategies. Trends Endocrinol Metab. 28(4): 250-260. Review. PMID: 27986466.
Patterson RE, Kalavalapalli S, Williams CM, Nautiyal M, Mathew JT, Martinez J, Reinhard MK, McDougall DJ, Rocca JR, Yost RA, Cusi K, Garrett TJ, Sunny NE. (2016) Lipotoxicity in steatohepatitis occurs despite an increase in tricarboxylic acid cycle activity. Am J Physiol Endocrinol Metab. 310(7): E484-94. PMID: 26814015.
Satapati S, Kucejova B, Duarte JA, Fletcher JA, Reynolds L, Sunny NE, He T, Nair LA, Livingston K, Fu X, Merritt ME, Sherry AD, Malloy CR, Shelton JM, Lambert J, Parks EJ, Corbin I, Magnuson MA, Browning JD, Burgess SC. (2015) Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver. J Clin Invest. 125(12):4447-4462. PMID: 26571396, PMCID: PMC4665800.
Sunny NE, Kalavalapalli S, Bril F, Garrett TJ, Nautiyal M, Mathew JT, Williams CM, Cusi K. (2015) Crosstalk between branched chain amino acids and hepatic mitochondria is compromised in nonalcoholic fatty liver disease. Am J Physiol Endocrinol Metab. 309(4):E311- E319. PMID: 26058864, PMCID: PMC4537921.
Satapati S*, Sunny NE, Kucejova B, Fu X, He T, Mendez-Lucas A, Shelton JM, Perales JC, Browning JD, Burgess SC. (2012) Elevated TCA cycle function in the pathology of diet induced hepatic insulin resistance and fatty liver. J. Lipid Res. 53(6) 1080-1092. PMID: 22493093.
Sunny NE, Parks EJ, Browning JD, Burgess SC. (2011) Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease(link is external). Cell Metab.14: 804-810. PMID: 22152305; Highlighted by Nature Reviews Endocrinology, Mitochondrial pathways in NAFLD. Highlighted by Science Daily, Fatty livers are in overdrive.
Sunny NE, Bequette BJ. (2011) Glycerol is a major substrate for glucose, glycogen and non essential amino acid synthesis in late term chicken embryos. J. Anim. Sci. 89: 3945-3953. PMID: 21764833.
Sunny NE, Satapati S, Fu X, He T, Mehdbeigi R, Spring-Robinson CL, Duarte J, Potthoff M, Browning J, Burgess SC. (2010) Progressive adaptation of ketogenesis in mice fed a high fat diet. Am J Physiol Endocrinol Metab. 298 (6) E1226-35. PMID: 20233938; PMCID: PMC2886525
Sunny NE, Bequette BJ. (2010) Gluconeogenesis differs in developing chick embryos derived from small compared with typical size broiler breeder eggs. J. Anim. Sci. 88:912-921. PMID: 19966165
Sunny NE, Owens SL, Baldwin VI RL, El-Kadi SW, Bequette BJ. (2007) Salvage of blood urea nitrogen in sheep is highly dependent upon plasma urea concentration and the efficiency of capture within the digestive tract. J. Anim. Sci. 85:1006–13. PMID: 17202392
Bequette BJ, Sunny NE, El-Kadi SW, Owens SL. (2006) Application of stable isotopes and mass isotopomer distribution analysis to the study of intermediary metabolism of nutrients. J. Anim. Sci. 84(E. Suppl.):E50–9. PMID: 16582092
Sunny Lab 